Most methods for analyzing biomolecular interactions produce averaged data from many thousands of molecules or more. A new generation of single-molecule biophysical techniques are transforming how we study biomolecular interactions, and can offer unparalleled insights into molecular heterogeneity, dynamic binding, and rare events. Understanding biomolecular interactions – the science of interactomics – is crucial for…

Magnetic Force Spectroscopy (MFS) is an analytical technique that directly probes the forces involved in individual biomolecular interactions. By taking this powerful approach and scaling it up to thousands of molecules in parallel, Depixus MAGNA One™ opens up a new world of insights into the intricate dynamics of biomolecular interactions that drive biological processes in…

Just as the advent of single-cell sequencing revolutionized genomics, Depixus MAGNA One™ is set to transform the field of interactomics. Built on magnetic force spectroscopy, this groundbreaking instrument enables unprecedented insights into thousands of individual biomolecular interactions. Breakthroughs in biology are driven by technological advances in scale and resolution Over the past two decades, we…

Protein-protein interactions (PPIs) lie at the heart of biology. Here we explain how Depixus MAGNA One™ can be used to analyze dynamic protein-protein interactions at scale, providing deep insights into biology and accelerating the development of novel therapeutics such as PPI inhibitors and molecular glues. What are protein-protein interactions and why are they important? Protein-protein…

We’ve been working with Dr Jay Schneekloth, a leading expert in RNA-targeted drug discovery, to use Depixus’ magnetic force spectroscopy (MFS) platform to probe the interactions between the PreQ1 bacterial riboswitch and its natural ligand or a synthetic small molecule. In a paper published in Nature Communications,1 we showed how our magnetic force spectroscopy technology…

Life runs on biomolecular interactions. A complex network of interactions between DNA, RNA, proteins, and other biomolecules underlies all biological processes. Studying these interactions is key to understanding how these processes work in health and disease, and for the development of more effective treatments. New technologies and therapeutic modalities are expanding the drug target universe…

Depixus MAGNA One™ provides a powerful new way to study biomolecular interactions at scale between DNA, RNA, proteins, antibodies, small molecules and more. Based on magnetic force spectroscopy (MFS), Depixus MAGNA One is the first laboratory instrument to deliver direct, real-time measurements of biomolecular interactions across thousands of individual molecules in parallel. What is magnetic…