Find out more about MAGNA One & the world of magnetic force spectroscopy
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| Brochure | |
|---|---|
| Description | Learn how Magnetic force spectroscopy is shaping the future of biomolecular analysis; understand how MAGNA One can impact your molecular research; & detailed product specifications |
| Keywords | MAGNA One, Magnetic Force Spectroscopy (MFS), specifications |
Videos, webinars, & presentations
| Video | |
|---|---|
| Description | See how MAGNA One can be used to study RNA structures & interactions |
| Summary | Depixus’ magnetic force spectroscopy instrument system can be used to study the biophysical properties of RNA structures and assess how they are impacted by binding small molecule drug candidates or RNA binding proteins |
| Video | |
|---|---|
| Description | See how MAGNA One can be used to study protein-to-protein interactions and the effect of modulators |
| Summary | Depixus’ magnetic force spectroscopy instrument system can be used to study protein-to-protein interactions (PPI) and assess the effect of modulators such as PPI inhibitors or molecular glues. Protein-antibody and protein-small molecule binding can also be assessed |
| Webinar | |
|---|---|
| Description | Biophysical Society Webinar 9th October 2024. See biology as it really happens – launch of a powerful magnetic force spectroscopy system to enable real-time study of the dynamics of individual molecular interactions at massive scale |
| Summary | Depixus’ CEO Gordon Hamilton explains the science behind Depixus MAGNA One and illustrates how it offers unprecedented real-time single molecule insights into biomolecular interactions using PPI data |
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Publications
Explore publications describing how magnetic force spectroscopy technology is being used to uncover new biological insights.
| Publication | |
|---|---|
| Description | Mechanistic analysis of Riboswitch Ligand interactions provides insights into pharmacological control over gene expression |
| Journal | Nature Communications 2024;15(1):8173 |
| Date | September 2024 |
| Summary | Using the PreQ1 riboswitch, this study highlights how Depixus’ magnetic force spectroscopy can provide exciting mechanistic insights into RNA-ligand binding, supporting the development of novel therapeutics |
| Prepublication | |
|---|---|
| Description | NMR structures and magnetic force spectroscopy studies of small molecules binding to models of an RNA CAG repeat expansion |
| Journal | BioArchive prepublication |
| Date | August 2024 |
| Summary | Expansion of CAG trinucleotide repeats is a hallmark of Spinocerebellar ataxia Type 3 (SCA3) and Huntington’s disease, and these expanded repeats sequester RNA-binding splicing factors, such as MBNL1, giving rise to splicing defects. Single molecule studies using Depixus’ magnetic force spectroscopy interrogated the mechanical effects of small molecules interacting with RNA repeat expansions and inhibit the binding of MBNL1 |
| Publication | |
|---|---|
| Description | Detection of genetic variation and base modifications at base-pair resolution on both DNA and RNA |
| Journal | Communications Biology 2021; 4(1):128 |
| Date | January 2021 |
| Summary | In this study, Depixus’ magnetic force spectroscopy is used to identify sequence variations and map a range of epigenetic base modifications in both DNA and RNA, including the FMR1 promotor region of DNA derived from a Fragile X carrier |
| Poster | |
|---|---|
| Description | Single molecule real-time analysis of dynamic nucleic acid interactions |
| Poster | Discovery on Target 2023, Boston |
| Date | September 2023 |
| Summary | This poster demonstrates the use of Depixus magnetic force spectroscopy platform to study biomolecular interactions including HIV-TAR RNA-ligand binding and protein-RNA binding exemplified by Dicer binding to a microRNA precursor |
Application notes
Explore a selection of our application notes, showing some of the uses of MFS and MAGNA One.
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| Application note | |
|---|---|
| Description | RNA-targeted drug discovery: Using Depixus MAGNA One to explore RNA-ligand interactions |
| Date | October 2024 |
| Summary | This application note explains the science behind the MAGNA One magnetic force spectroscopy platform and explains the different ways it can be applied to study RNA-ligand interactions |
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| Application note | |
|---|---|
| Description | RNA-targeted drug discovery: Using Depixus MAGNA One to analyze riboswitch-ligand interactions |
| Date | October 2024 |
| Summary | This application note demonstrates the use of Depixus’ magnetic force spectroscopy platform to explore riboswitch-ligand interactions, presenting a mechanistic comparison of the binding of a synthetic small molecule and the natural PreQ1 ligand to the PreQ1 riboswitch |
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| Application note | |
|---|---|
| Description | Molecular glues: Using Depixus MAGNA One to analyze protein-protein interactions |
| Date | November 2024 |
| Summary | This application note explains the use of Depixus MAGNA One to explore the dynamics of protein-protein interactions and demonstrates how it can be used to study molecular glues and assess the binding strength of the ternary complexes |
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| Application note | |
|---|---|
| Description | RNA-targeted drug discovery: Using MAGNA One to gain insights into RNA-small molecule binding |
| Date | January 2025 |
| Summary | This application note showcases the use of Depixus’ magnetic force spectroscopy technology to measure the kinetics of small molecules binding to HIV-TAR RNA and to assess the impact of ligand binding on the structural stability the RNA structure. |
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| Application note | |
|---|---|
| Description | RNA-targeted drug discovery: Why we need an improved analytical technique |
| Date | January 2025 |
| Summary | We discuss the enormous potential of RNA as a therapeutic target and highlight the need for an improved analytical technique. We demonstrate how MAGNA One’s unique benefits will meet this need and bring a deeper understanding of how drugs interact with, and affect, these complex molecules. |