Find out more about MAGNA One & the world of magnetic force spectroscopy
Recent & upcoming events
From international conferences to virtual seminars, join us at upcoming events to learn more about Depixus, engage with our experts, and find out what our technology can do for you.
| Conference | |
|---|---|
| Description | Visit us at Booth #714 and attend our presentation, MAGNA One™ – Single-Molecule Magnetic Force Spectroscopy, showcasing real-time insights into biomolecular interactions |
| When? | 15th February - 19th February 2025 |
| Where? | Los Angeles, USA |
| Conference | |
|---|---|
| Description | Join us at the Drug Discovery Innovative Program to explore how our technology is revolutionizing real-time biomolecular research and advancing therapeutic innovation |
| When? | 3rd March - 4th March 2025 |
| Where? | San Diego, USA |
| Conference | |
|---|---|
| Description | Meet us at the Applied Biophysics Forum in Drug Delivery to explore how our system is advancing biophysics research and transforming drug discovery |
| When? | 11th March - 12th March 2025 |
| Where? | Mainz, Germany |
| Conference | |
|---|---|
| Description | Find us at Booth #401, to discover how the Depixus MAGNA One is redefining biomolecular research and driving the future of therapeutic breakthroughs |
| When? | 14th April - 17th April 2025 |
| Where? | San Diego, USA |
| Conference | |
|---|---|
| Description | Depixus had two oral presentations and exhibited MAGNA One at Booth #515 |
| When? | 30th September - 3rd October 2024 |
| Where? | Boston, USA |
We also regularly give talks and seminars at research institutions and companies to introduce Depixus’ MFS technology. If you’re interested in us visiting your organization, then do get in touch →
Request here →
| Brochure | |
|---|---|
| Description | Learn how MFS is shaping the future of biomolecular analysis; understand how MAGNA One can impact your molecular research; & detailed product specifications |
| Keywords | MAGNA One, Magnetic Force Spectroscopy (MFS), specifications |
Videos, webinars, & presentations
| Video | |
|---|---|
| Description | See how MAGNA One can be used to study RNA structures & interactions |
| Summary | Depixus’ magnetic force spectroscopy instrument system can be used to study the biophysical properties of RNA structures and assess how they are impacted by binding small molecule drug candidates or RNA binding proteins |
| Video | |
|---|---|
| Description | See how MAGNA One can be used to study protein-to-protein interactions and the effect of modulators |
| Summary | Depixus’ magnetic force spectroscopy instrument system can be used to study protein-to-protein interactions (PPI) and assess the effect of modulators such as PPI inhibitors or molecular glues. Protein-antibody and protein-small molecule binding can also be assessed |
| Webinar | |
|---|---|
| Description | Biophysical Society Webinar 9th October 2024. See biology as it really happens – launch of a powerful magnetic force spectroscopy system to enable real-time study of the dynamics of individual molecular interactions at massive scale |
| Summary | Depixus’ CEO Gordon Hamilton explains the science behind Depixus MAGNA One and illustrates how it offers unprecedented real-time single molecule insights into biomolecular interactions using PPI data |
Request here →
Publications
Explore a selection of relevant peer-reviewed papers and preprints, describing how leading researchers are using MAGNA One – and MFS more generally – to uncover new biological insights.
| Publication | |
|---|---|
| Description | Mechanistic analysis of Riboswitch Ligand interactions provides insights into pharmacological control over gene expression |
| Journal | Nature Communications 2024;15(1):8173 |
| Date | September 2024 |
| Summary | Using the PreQ1 riboswitch, this study highlights how Depixus’ magnetic force spectroscopy can provide exciting mechanistic insights into RNA-ligand binding, supporting the development of novel therapeutics |
| Prepublication | |
|---|---|
| Description | NMR structures and magnetic force spectroscopy studies of small molecules binding to models of an RNA CAG repeat expansion |
| Journal | BioArchive prepublication |
| Date | August 2024 |
| Summary | Expansion of CAG trinucleotide repeats is a hallmark of Spinocerebellar ataxia Type 3 (SCA3) and Huntington’s disease, and these expanded repeats sequester RNA-binding splicing factors, such as MBNL1, giving rise to splicing defects. Single molecule studies using Depixus’ magnetic force spectroscopy interrogated the mechanical effects of small molecules interacting with RNA repeat expansions and inhibit the binding of MBNL1 |
| Publication | |
|---|---|
| Description | Detection of genetic variation and base modifications at base-pair resolution on both DNA and RNA |
| Journal | Communications Biology 2021; 4(1):128 |
| Date | January 2021 |
| Summary | In this study, Depixus’ magnetic force spectroscopy is used to identify sequence variations and map a range of epigenetic base modifications in both DNA and RNA, including the FMR1 promotor region of DNA derived from a Fragile X carrier |
| Poster | |
|---|---|
| Description | Single molecule real-time analysis of dynamic nucleic acid interactions |
| Poster | Discovery on Target 2023, Boston |
| Date | September 2023 |
| Summary | This poster demonstrates the use of Depixus magnetic force spectroscopy platform to study biomolecular interactions including HIV-TAR RNA-ligand binding and protein-RNA binding exemplified by Dicer binding to a microRNA precursor |
Application notes
Explore a selection of our application notes, showing some of the uses of MFS and MAGNA One.
Request here →
| Application note | |
|---|---|
| Description | RNA-targeted drug discovery: Using Depixus MAGNA One to explore RNA-ligand interactions |
| Date | October 2024 |
| Summary | This application note explains the science behind the MAGNA One magnetic force spectroscopy platform and explains the different ways it can be applied to study RNA-ligand interactions |
Request here →
| Application note | |
|---|---|
| Description | RNA-targeted drug discovery: Using Depixus MAGNA One to analyze riboswitch-ligand interactions |
| Date | October 2024 |
| Summary | This application note demonstrates the use of Depixus’ magnetic force spectroscopy platform to explore riboswitch-ligand interactions, presenting a mechanistic comparison of the binding of a synthetic small molecule and the natural PreQ1 ligand to the PreQ1 riboswitch |
Request here →
| Application note | |
|---|---|
| Description | Molecular glues: Using Depixus MAGNA One to analyze protein-protein interactions |
| Date | November 2024 |
| Summary | This application note explains the use of Depixus MAGNA One to explore the dynamics of protein-protein interactions and demonstrates how it can be used to study molecular glues and assess the binding strength of the ternary complexes |