CareersJoin the Depixus® team

Depixus® is operating in one of the most dynamic and exciting areas of bioscience today. We are seeking highly talented individuals to join our teams based in both Paris, France and Cambridge, UK.

Technical excellence is very important but you will also need to be innovative, enterprising, and enjoy working within a close-knit team. The development of our technology requires scientists and engineers from a wide range of disciplines.

We accept resumes at all times; if you think you could help us then we would love to hear from you! For more information please contact: jobs@depixus.com. Positions that are currently open are listed below.

Current Vacancies in Paris (FR)

Depixus is a young and fast-growing biotechnology company based in both Paris, France and Cambridge, UK. Our aim is to commercialize a highly innovative technology platform for the fast, accurate, and inexpensive extraction of genetic and epigenetic information from single molecules of DNA and RNA. Originally developed in the Physics Department of École Normale Supérieure (ENS) in Paris, the potential of this exciting technology has been recognized through the award of numerous grants and prizes for innovation at both national and international levels. You can read more about Depixus on our website (www.depixus.com).

Depixus currently has an open position for a full-time Mechanical Engineer to work on various projects related to the development of our technology platform. This is a rare opportunity to play an important role in the development of a cutting-edge technology, and as part of a dynamic early-stage company.

Job Description

We are seeking an exceptional individual who enjoys working in a highly collaborative and fast paced R&D environment to join our multidisciplinary team. The successful candidate will work with biologists, engineers, physicists, and software engineers, both within Depixus and as part of collaborations with academic and OEM partners. He/she will play an important role in the commercialization of our innovative new technology platform for the identification, sequencing, and epigenetic analysis of DNA and RNA.

The successful candidate will be part of Depixus’ fast-growing engineering team and will be based primarily in Paris, France. He/she will work in close collaboration with the other team members to produce a scientific-grade instrument, with high overall product performance and stability requirements. More specifically, he/she will:

  • develop the mechanical layout of the optical components of Depixus’ instrument systems
  • produce CADs of the complete instrument system and cartridge elements
  • prototype and industrialize key opto-mechanical sub-elements of the instrument
  • plan and perform instrument validation and verification testing

Close engagement with external partners will be important. Similarly, close collaboration with other Depixus teams will also be critical to ensure that the hardware platform is compatible with other requirements of the technology (e.g. biological sample preparation, surface chemistries, software, cartridge design, etc.).

Overall, this role would suit candidates with a solid background in the development of scientific instruments for biomedical applications (ideally genetic analysis).

 

Required Qualifications, Experience, and Qualities

 

  • Masters-level or PhD level qualification in the field of mechanical or opto-mechanic engineering
  • Excellent skills in CAD design tools (ideally SolidWorks)
  • Industry experience of the design and development of scientific instrumentation
  • Demonstrated ability to deliver high-quality solutions to difficult challenges
  • Demonstrated willingness to take ownership of individual and team tasks
  • Excellent interpersonal and communications skills
  • Both a team-player and able to work autonomously
  • Highly motivated and results-driven
  • A good command of spoken and written English

Desirable Qualifications & Experience

 

  • Previous experience in microscopy or complex optomechanical systems
  • Experience in genetic sequencing or other biotechnology instrument development is a big plus but not essential
  • Previous experience with flexure systems and/or microfluidic cartridge modules would be useful
  • Knowledge of high precision mechanical machining tools
  • Familiarity with thermal control of instruments

Responsibilities

 

  • The successful candidate will:
    • develop the mechanical layout of the optical components of Depixus’ instrument systems
    • produce CADs of the complete instrument system and cartridge elements
    • prototype and industrialize key opto-mechanical sub-elements of the instrument
    • plan and perform instrument validation and verification testing
  • Contribute to internal and external, informal and formal design reviews
  • Participate in group meetings, and presentation of work to group members
  • Support and advise on other engineering matters related to development of Depixus’ innovative instrument systems.

Location

 

  • The job will be based primarily in Depixus’ offices/labs in Paris, France, with the possibility of occasional travel to the company’s offices/labs in Cambridge U.K.

 

Application procedure

Please send a current C.V. and cover letter via email to Depixus’ Chief Technology Officer, Chas Andre, at: chas.andre@depixus.com

Current Vacancies in Cambridge (UK)

Depixus is a young and fast-growing biotechnology company based in both Paris, France and Cambridge, UK. Our aim is to commercialize a highly innovative technology platform for the fast, accurate, and inexpensive extraction of genetic and epigenetic information from single molecules of DNA and RNA. Originally developed in the Physics Department of École Normale Supérieure (ENS) in Paris, the potential of this exciting technology has been recognized through the award of numerous grants and prizes for innovation at both national and international levels. You can read more about Depixus on our website (www.depixus.com).

Depixus currently has an open position for a full-time Senior Mechanical Design Engineer to work on various projects related to the development of our technology platform. This is a rare opportunity to play an important role in the development of a cutting-edge technology, and as part of a dynamic early-stage company.

Job Description

We are seeking an exceptional individual who enjoys working in a highly collaborative and fast paced R&D environment to join our multidisciplinary team. The successful candidate will work with biologists, engineers, physicists and software engineers, both within Depixus and as part of collaborations with academic and OEM partners. They will play an important role in the commercialization of our innovative new technology platform for the identification, sequencing, and epigenetic analysis of DNA and RNA.

The successful candidate will be part of Depixus’ engineering team and will be based primarily in Harston, Cambridgeshire, UK. They will be working on several mechanical challenges in our current and future instrument platforms. They will take ownership of the whole mechanical system and its subsystems for our digital genetic analysis platform. These systems include DNA/RNA sample preparation and analysis of biological materials incorporating microfluidics, fluidic handling, biochemistry, thermal sensing and control, electronics, optics and mechanical functional modules. They will be a key contributor to the platform development from requirement gathering, concept generation, design prototyping, design implementation, fabrication, test and integration. They will develop test strategies, perform risk analysis, troubleshoot interdisciplinary electromechanical and fluidics systems, identify root cause and implement corrective actions during the product development.  They will engage in developing the instrument and guiding development process through to volume production under relevant regulatory safety standards and directories. Therefore, familiarity with CE marking, FDA approval process and QMS in medical device is beneficial.

More generally, the successful candidate will contribute to the overall development of the company’s technology platform. This will include the development and test of various mechanical and fluidics modules within the instrument platform. Close engagement with external partners, manufacturers and test houses will be important. Similarly, close collaboration with other Depixus teams will also be critical to ensure a seamless integration of all functional blocks.

Overall, this role would suit candidates that have a solid background in the mechanical and microfluidics engineering, especially in biomedical applications. Previous experience in the development of systems-on-chip for genetic analysis would be of great value.

 

Required Qualifications, Experience, and Qualities

  • BS/MS/PhD in mechanical engineering or biomedical engineering with a minimum of 10 years relevant industry experience
  • Experienced in at least three of the following areas: control systems, system integration, mass flow and thermodynamics, microfluidics systems, injection moulding and/or optical systems
  • Highly competent in generating mechanical design drawings using Solidworks or other similar mechanical design toolboxes
  • Proficient with performing finite element modelling for fluidics systems and thermodynamic systems
  • Experience with the design, fabrication and test of complex and low-cost microfluidic devices using biocompatible materials and injection moulding techniques, in both prototype quantities and full-scale manufacturing
  • Demonstrated experience with experimental design, failure analysis and root cause analysis
  • Demonstrated hands on engineering capability with proven track record of high quality designs that met product requirements on time and on budget
  • Excellent interpersonal and communications skills
  • Both a team-player and able to work autonomously
  • Highly motivated and results-driven

Desirable Qualifications & Experience

  • Experience with MEMS fabrication and nanofabrication
  • Experience with interfacing with biochemistry, surface chemistry and electronic engineering teams
  • Knowledge of software programming or electronic engineer design at system level
  • Knowledge and skills in process and product validation of a variety of equipment and processes used to build medical products, particularly ISO 13485 and FDA QSR experience preferred.
  • General familiarity with life sciences is advantageous but not required

Responsibilities

  • Supporting the development of Depixus’ innovative MAGNA digital instrument platform for combined genetic and epigenetic analysis.
  • Specifically:
    • Lead the mechanical design involved in the instrument platform development
    • Develop and refine the sample preparation process flow
    • Design, build, verify and validate the mechanical and microfluidics devices for the existing platform and platform under development
    • Collaborate with external partners in product design, fabrication and test
    • Engage in the system integration of the platform and its subsystems
  • Contribution to internal and external, informal and formal design reviews
  • Participation in group meetings, and presentation of work to group members

Location

  • The job will be based primarily in Depixus’ offices/labs in Harston, Cambridge, U.K. but will also involve frequent travel to the company’s offices/labs in Paris,

 

Application procedure

Please send a current C.V. and cover letter via email to Depixus’ Chief Technology Officer, Chas Andre, at: chas.andre@depixus.com