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MAGNA™ is a revolutionary single molecular analysis platform that offers a powerful new way to prove complex biomolecular interactions, unlocking critical and unique structural insights.
MAGNA™ is a revolutionary single molecule analysis platform that offers a powerful new way to probe complex biomolecular interactions. Based on established magnetic tweezer technology, MAGNA™ precisely measures changes in the biophysical properties of individual three-dimensional molecular structures, in real time, capturing vital information about binding events and their impact on structural dynamics, binding kinetics and mechanism of action.
With MAGNA™, molecules can be rapidly identified using just a small number of molecular probes. Sequence variability can also be analysed via the same approach.
Base modification detection with MAGNA™ doesn’t require conversion chemistries. A wide range of modifications can be detected and located in a single run with unparalleled levels of precision.
MAGNA™ can also analyse how biomolecules interact with each other. The kinetics of attachment or detachment (Kon, Koff, and Kd) can be measured, providing a powerful new dimension with which to study complex biological process at the molecular level.
We’re developing kits for rapid preparation of samples for analysis.
Analysis is performed using a dedicated cartridge and flow cell.
Data is generated in real-time from a small bench-top instrument.
Zhen Wang, Jérôme Maluenda, Laurène Giraut, Thibault Vieille, Andréas Lefevre, David Salthouse, Gaël Radou, Rémi Moulinas, Sandra Astete, Pol D’Avezac, Geoff Smith, Charles André, Jean-François Allemand, David Bensimon, Vincent Croquette, Jimmy Ouellet & Gordon Hamilton
Communications Biology volume 4, Article number: 128 (2021)
https://www.nature.com/articles/s42003-021-01648-7
